Tag: AMINO ACID
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The drug phencyclidine (PCP or ‘Angel Dust’) antagonizes glutamic acid non-competitively at the NMDA receptor
The drug phencyclidine (more commonly known as PCP or ‘Angel Dust’) antagonizes glutamic acid non-competitively at the NMDA receptor. For the same reasons, dextromethorphan and ketamine also have strong dissociative and hallucinogenic effects. Acute infusion of the drug LY354740 (also known as eglumegad, an agonist of the metabotropic glutamate receptors2 and 3) resulted in a marked diminution of yohimbine-induced stress response in bonnet macaques (Macaca radiata); chronic oral administration of LY354740 in those animals led to markedly reduced baseline cortisol levels…
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Oxalyldiaminopropionic acid (ODAP) is a structural analogue of the neurotransmitter glutamate found in the grass pea Lathyrus sativus
Oxalyldiaminopropionic acid (ODAP) is a structural analogue of the neurotransmitter glutamate found in the grass pea Lathyrus sativus. It is the neurotoxin responsible for the motor neuron degeneration syndrome lathyrism. Woldeamanuel, Yohannes W.; Hassan, Anhar; Zenebe, Guta (2011-11-12). “Neurolathyrism: two Ethiopian case reports and review of the literature”. Journal of Neurology. 259 (7): 1263–1268. doi:10.1007/s00415-011-6306-4. ISSN 0340-5354. PMID 22081101. S2CID 27543906. Sources ODAP is found in the seeds of the legume L. sativus, a grass pea…
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Tryptophan tryptophylquinone (TTQ) formation
Tryptophan tryptophylquinone (TTQ) is an enzyme cofactor, generated by posttranslational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function. From Wikipedia where this page was last updated June 22, 2022 See also Amicyanin is a type I copper protein that plays an integral role in electron transfer. In bacteria such as Paracoccus denitrificans, amicyanin is part of a three-member redox complex, along…
NOTES
- 🧬 Disease Table with Low Sodium Connection
- 🧂 Sodium Reduction and Sodium Replacement: A History of Reformulation and Exploding Diseases, Including Many Diseases Unheard of Before Deadly Sodium Policies
- 🧂 The DEADLY 1500 mg Sodium Recommendation predates the WHO’s formal global sodium reduction push by nearly a decade (and it’s even worse than that)
- 🧬 What Is Beta-Glucuronidase?
- When Sugar Was Salt: Crystalline Confusion and the Covenant of Sweetness
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