Tag: Cancer
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Phosphopyruvate hydratase, aka enolase, is a metalloenzyme that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis
Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is:2-phospho-D-glycerate ⇌ phosphoenolpyruvate + H2O Phosphopyruvate hydratase belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). The reaction is reversible, depending on environmental concentrations of…
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Gastrin-releasing peptide aka GRP
Gastrin-releasing peptide, also known as GRP, is a neuropeptide, a regulatory molecule that has been implicated in a number of physiological and pathophysiological processes. Most notably, GRP stimulates the release of gastrin from the G cells of the stomach. The gene from which GRP is derived encodes a number of bombesin-like peptides. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to…
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p300-CBP coactivator family – clinical significance
Mutations in CBP, and to a lesser extent p300, are the cause of Rubinstein-Taybi Syndrome, which is characterized by severe mental retardation. These mutations result in the loss of one copy of the gene in each cell, which reduces the amount of CBP or p300 protein by half. Some mutations lead to the production of a very…
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Histone acetyltransferase p300
Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions…
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CBP has been shown to play a role in every stage of tumor development
Due to its critical role in regulation of cell proliferation, growth, migration and apoptosis, it is considered to be an oncogene, or tumor suppressor. Contrarily To date, increased CBP activity has been implicated in a variety of different malignancies including breast cancer, lung cancer, prostate cancer, colorectal cancer, acute leukemias, head and neck cancer, and many others. According to the Catalog…
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CBP has intrinsic acetyltransferase functions
Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREB-binding protein), also known as CREBBP or CBP or KAT3A, is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3. CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to alter chromatin structure making genes more accessible for transcription. This relatively…
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Xylose is the first saccharide added to the serine or threonine in the proteoglycan type O-glycosylation
Xylose is the first saccharide added to the serine or threonine in the proteoglycan type O-glycosylation, and, so, it is the first saccharide in biosynthetic pathways of most anionic polysaccharides such as heparan sulfate and chondroitin sulfate. Definitions Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a “core protein” with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through…
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Mauveine aka aniline purple
Mauveine, also known as aniline purple and Perkin’s mauve, was one of the first synthetic dyes. It was discovered serendipitously by William Henry Perkin in 1856 while he was attempting to synthesise the phytochemical quinine for the treatment of malaria. It is also among the first chemical dyes to have been mass-produced. Chemistry Mauveine is a mixture of four related aromatic compounds differing in number and placement of methyl…
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Interleukin-2-recptor alpha chain (IL2RA also called CD25) is the human protein encoded by the IL2RA gene.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced…
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Cadherin-1
Cadherin-1 or Epithelial cadherin(E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1gene.[5] Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.[6][7] History The discovery of cadherin cell-cell adhesion proteins is attributed to Masatoshi Takeichi, whose experience…
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Microphthalmia-associated transcription factor aka class E basic helix-loop-helix protein 32 or bHLHe32
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene. AKA MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription factor, MITF-A RNA expression pattern Human Mouse (ortholog) Top expressed inretinal pigment epitheliumright ventriclemyocardiumvastus lateralis muscledeltoid muscleurethrarenal medullavisceral pleurasaphenous veinsecondary oocyte Top…
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Calcitonin
Calcitonin is a 32 amino acid peptide hormone secreted by PARAFOLLICULAR CELLS (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of PARATHYROID HORMONE (PTH). Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the…
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Melanin-concentrating hormone (MCH) aka PMCH
Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamicpeptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation. Barson JR, Morganstern I, Leibowitz SF (2013). “Complementary roles of orexin and melanin-concentrating hormone in feeding behavior”. International Journal of Endocrinology. 2013: 983964. doi:10.1155/2013/983964. PMC 3727095. PMID 23935621. In mammals it is involved in the regulation of feeding behavior, mood,…
