Tag: Chromosome 11

  • YAP1 

    YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases.[5]YAP1 is a potent oncogene, which is…

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  • Calcitonin

    Calcitonin

    Calcitonin is a 32 amino acid peptide hormone secreted by PARAFOLLICULAR CELLS (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of PARATHYROID HORMONE (PTH). Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the…

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