Tag: Parke-Davis

  • Quadrigen (DPT combined with the Salk polio vaccine) – random notes

    In 1959, the Parke-Davis Quadrigen vaccine (DPT combined with the Salk polio vaccine) is licensed. The vaccine is alleged to be particularly reactive because of the effect of the preservative on the pertussis component. Several lawsuits ensue. The vaccine is withdrawn from the market in 1968 (Coulter and Fisher, 1985). Institute of Medicine (US) Committee…

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  • The molecular mayhem of immunogens, haptens, carriers and adjuvants

    The molecular mayhem of immunogens, haptens, carriers and adjuvants

    First up, the immunogen: the molecular maestro of the immune system, orchestrating a symphony of B-cells and T-cells like a conductor with a grudge. These substances don’t just knock politely on the immune system’s door—they kick it down with the force of a battering ram. Immunogens are a subset of antigens (because “antibody-generating” wasn’t obvious enough)…

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